Notch Signaling in Embryology and Cancer: Notch Signaling in Cancer
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Author(s): Jörg Reichrath, Sandra Reichrath
Series: Advances in Experimental Medicine and Biology 1287 Publisher: Springer International Publishing;Springer, Year: 2021 ISBN: 9783030550301,9783030550318 Description:
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more.
Taken as a whole, with its companion books — Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students. |
Table of contents : Front Matter ….Pages i-xvii Notch Signaling in Prevention And Therapy: Fighting Cancer with a Two-Sided Sword (Jörg Reichrath, Sandra Reichrath)….Pages 1-7 Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response (Benedetto Daniele Giaimo, Ellen K. Gagliani, Rhett A. Kovall, Tilman Borggrefe)….Pages 9-30 Unravelling of Hidden Secrets: The Tumour Suppressor Lethal (2) Giant Discs (Lgd)/CC2D1, Notch Signalling and Cancer (Tobias Reiff, Miriam Baeumers, Christine Tibbe, Thomas Klein)….Pages 31-46 Notch and Endometrial Cancer (Violeta Jonusiene, Ausra Sasnauskiene)….Pages 47-57 NOTCH and Esophageal Squamous Cell Carcinoma (Yong Li, Yahui Li, Xiaoxin Chen)….Pages 59-68 Notch Signaling and Liver Cancer (Kazunori Kawaguchi, Shuichi Kaneko)….Pages 69-80 Notch in Head and Neck Cancer (Cristina Porcheri, Thimios A. Mitsiadis)….Pages 81-103 Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis (Trinath Das, Rong Zhong, Michael T. Spiotto)….Pages 105-122 The Impact of Notch Signaling for Carcinogenesis and Progression of Nonmelanoma Skin Cancer: Lessons Learned from Cancer Stem Cells, Tumor Angiogenesis, and Beyond (Jörg Reichrath, Sandra Reichrath)….Pages 123-154 Notch Signaling in Thyroid Cancer (Rachael Guenter, Zeelu Patel, Herbert Chen)….Pages 155-168 The Relevance of Notch Signaling in Cancer Progression (Fasoulakis Zacharias, Daskalakis George, Theodora Marianna, Antsaklis Panos, Sindos Michael, Diakosavvas Michail et al.)….Pages 169-181 Notch Signaling and the Breast Cancer Microenvironment (Qiang Shen, Michael Reedijk)….Pages 183-200 Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy (Giulia Monticone, Lucio Miele)….Pages 201-222 Correction to: Notch Signaling and Human Papillomavirus–Associated Oral Tumorigenesis (Trinath Das, Rong Zhong, Michael T. Spiotto)….Pages C1-C1 Back Matter ….Pages 223-228 |
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